Mittwoch, 29. November 2017, 16:15 - 17:45 iCal

Huang Mia, PhD /

UCSD, Department of Chemistry & Biochemistry

"Chemical control of the glycocalyx to modulate differentiation and development"

Kleiner Hörsaal 3 der Fakultät für Chemie
Währinger Straße 38, 1090 Wien


Chemical control of the glycocalyx to modulate differentiation and development


The cellular fate of embryonic stem cells and their subsequent development into differentiated cells are governed by precise growth factor signaling events at the stem cell surface. Such events are often orchestrated by heparan sulfate proteoglycans (HSPGs), which template growth factor binding to their corresponding receptors. Given the structural complexity of HSPGs, however, methods to manipulate them to study their function has been limited. Here, we report a suite of chemical strategies that exploit the function of HSPGs to control pluripotency or trigger the differentiation of mouse embryonic stem cells. To this end, we employ small molecules targeting the glycosaminoglycan (GAG) side chains of HSPGs to maintain pluripotency, and design GAG-mimetic molecules that can recapitulate the functions of native GAGs.


Fakultät für Chemie, Institut für Organische Chemie


Brigitte Schwarz
Fakultät für Chemie der Universität Wien