Mittwoch, 30. November 2016, 16:15 - 17:45 iCal

Dr. Hubert Gstach

Universität Wien, Medizinische Universität Wien

"Design of an Aminoalcohol Antimalarial with picomolar Activity against Chloroquine Resistant Plasmodium Falciparum"

Hörsaal 3 der Fakultät für Chemie
Währinger Straße 38, 1090 Wien


The seminar contribution will describe the long way of a University project, which started from a lousy hit and matured finally in a drug candidate. Scpecial attention will be given to structural work. Combined spectroscopic studies by NMR, IR, and X-ray will be presented.

The structural investigations revealed a cooperative multicenter hydrogen bonding controlling the overall conformation of the molecules, and thereby also the flexible amino alcohol

pharmacophor. The complex network of hydrogen bonds created the most active amino alcohol antimalarials known today. The conclusions taken from these structural investigations will lead to a comparison with known amino alcohol drugs. A proposal for identifying the unknown target of these compound class will be included.


Fakultät für Chemie, Institut für Organische Chemie


Brigitte Schwarz
Fakultät für Chemie der Universität Wien