Mittwoch, 26. Juni 2019, 13:00 - 14:30 iCal

The Neuroscience of Major Depression

Focus on Anhedonia

Talk of Diego Pizzagalli, Ph.D.

Fakultät für Psychologie, Hörsaal G, 2. Stock (linke Stiege)
Liebigasse 5, 1010 Wien


Anhedonia – the loss of pleasure or lack of reactivity to pleasurable stimuli – is a core symptom of depression and a potential risk factor for various forms of psychopathology. Few studies to date have employed laboratory-based measures to objectively characterize this important depressive phenotype. Further, although preclinical data have emphasized stress-mediated disturbances of mesocorticolimbic dopaminergic functions in the pathophysiology of depression, the mechanisms and substrates underlying these processes are largely unknown in humans. Findings from recent studies in Dr. Pizzagalli’s laboratory combining behavioral, functional neuroimaging, and pharmacological approaches to study the neurobiology of anhedonia will be reviewed. Collectively, these findings indicate that depression is characterized by an impaired tendency to modulate behavior as a function of prior reinforcements and dysfunction in brain reward pathways. The potential clinical implications of these findings will be discussed.






Department of Basic Psychological Research and Research Methods (SCAN Unit)


Abla Marie-Jose Bedi
Institut für Psychologische Grundlagenforschung und Forschungsmethoden