Mittwoch, 17. Mai 2017, 15:30 - 17:00 iCal
Dr. Luca Salassa /
Denostia International Physics Center, Spain
"Unconventional Photoactivation Strategies For Anticancer Metal-Based Prodrugs"
Seminarraum 2 der Fakultät für Chemie
Währinger Straße 42, 1090 Wien
Vortrag
Unconventional Photoactivation Strategies For Anticancer Metal-Based Prodrugs
In the last few years, photoactivatable transition metal complexes have been studied intensively as alternative photodynamic therapy (PDT) prodrugs.[1] Metals play a key role in medicine and the uniquely rich photochemistry of transition metal complexes can be tailored to promote novel light-induced anticancer mechanisms of action.
Nevertheless, this class of compounds generally displays poor absorption properties in the therapeutic window of the visible spectrum, posing a fundamental limitation for further advancing their use towards preclinical and clinical stages.
In this contribution I will discuss how my group is addressing such issue by developing new photochemistry approaches based on upconverting nanomaterials[2] and bioorthogonal photocatalysis.
[1] Schatzschneider U., Eur. J. Inorg. Chem., 2010, 10, 1451.
[2] a) Ruggiero E., Habtemariam A., Yate L., Mareque-Rivas J. C., Salassa L., Chem. Commun., 2014, 50, 1715; b) Ruggiero E., Hernández-Gil J., Mareque-Rivas J. C., Salassa L., Chem. Commun., 2015, 51, 2091; c) Ruggiero E., Garino C., Mareque-Rivas J. C., Habtemariam A., Salassa L., Chem. Eur. J., 2016, 22, 2801.
Veranstalter
Kontakt
Brigitte Schwarz
Fakultät für Chemie der Universität Wien
Dekanat
01/4277-52006
brigitte_schwarz@univie.ac.at
Erstellt am Mittwoch, 05. April 2017, 11:24
Letzte Änderung am Mittwoch, 05. April 2017, 12:45