Donnerstag, 11. Mai 2017, 17:00 - 19:00 iCal

Dr. Alexey Nazarov /

Department of Medicinal Chemistry and Fine Organic Synthesis,

Faculty of Chemistry, M.V. Lomonosov Moscow State University


"Novel anticancer metal based compounds to interefere with cellular processes"

Joseph Loschmidt Hörsaal der Fakultät für Chemie
Währinger Straße 42, 1090 Wien


Novel anticancer metal based compounds to interfere with cellular processes


Platinum complexes belong to the most widely applied anticancer chemotherapeutics. One of the biggest drawbacks of these compounds is their low selectivity for tumour tissue. Ruthenium compounds are in the focus of search for new anticancer drugs and it was shown that the ligand sphere strongly influences their anticancer and antimetastatic properties.

Different approaches have been explored in design of metal-based anticancer complexes, including synthesis of mono- and bifunctional compounds, specific targeting kinase and proteins.

This presentation will focus on targeting of several cellular processes highly specific for the cancer cell. New compounds may interfere with the glycolysis, activity of the retinoid X receptor or angiogenesis. The structural modification with regard to the ligand, the leaving group, and the oxidation state of metal is discussed. The complexes showed excellent in vitro cytotoxicity in number of the human cancer cell lines and some of them in vivo anti-angiogenic activity.


Fakultät für Chemie


Brigitte Schwarz
Fakultät für Chemie der Universität Wien