Freitag, 31. Mrz 2017, 15:00 - 17:00 iCal

Prof. Dr. Mika Linden /

Universität Ulm, Institut für Anorganische Chemie

"Mesoporous silica nanoplarticles for cell-directed drug delivery"

Seminarraum 2 der Fakultät für Chemie
Währinger Straße 42, 1090 Wien

Vortrag


Mesoporous silica nanoplarticles for cell-directed drug delivery

Mesoporous silica nanoparticles (MSNs) have attracted immense interest as drug carriers over the last years, and successful targeted drug delivery has been demonstrated in vitro and occasionally in vivo in small animal models. The flexibility in terms of particle size, shape, and surface chemistry makes it possible to fine-tune the physical and chemical properties to correspond to the requirements of a specific administration route. Furthermore, their high surface area and pore volumes allow high drug loadings to be achieved, which also lower the nanoparticle loadings needed in a therapeutic setting. The particles are biocompatible and biodegradable and are typically renally excreted. The presentation will critically discuss factors influencing cellular specificity upon receptor-mediated targeting of such particles, with special focus on the influence of the protein corona formed on the particles in serum. Results will be shown which challenge the common view that a minimum level of protein adsorption is beneficial for enhanced cellular specificity. In addition, protein adsorption to the particles will also be discussed on a particle level, and it will be shown that results obtained from ensemble analyses do not reflect the large particle-to-particle differences in terms of serum protein adsorption. Furthermore, the biodistribution and factors influencing tumor accumulation of will be discussed based on quantitative PET imaging results. Special focus is laid on the discrimination between factual particle accumulation in organs and particles present in the organ vasculature. Influences of tumor vascularization on particle accumulation will also be discussed, highlighting the urgent need for standardization in order to allow for a better comparison between studies.


Veranstalter

Fakultät für Chemie


Kontakt

Brigitte Schwarz
Fakultät für Chemie der Universität Wien
Dekanat
01/4277-52006
brigitte_schwarz@univie.ac.at