Donnerstag, 19. Oktober 2017, 17:00 - 18:00 iCal

Guest Lecture by by Delia BELELLI, PhD

GABAA receptors in health and disease

UZA 2, Lecture Hall 6
Althanstraße 14, 1090 Wien


The Doctoral Program ION CHANNELS AND TRANSPORTERS AS MOLECULAR DRUG TARGETS („MolTag“) is pleased to invite you to the following lecture


GABAA receptors in health and disease

by Delia BELELLI, PhD

Division of Pharmacology and Neuroscience, Univ. of Dundee

on: Thursday, October 19th 2017, 05:00 pm (17:00 Uhr)

at: UZA 2, Althanstr. 14, 1090 Vienna, LECTURE HALL 6


GABAA receptors mediate the majority of inhibitory neurotransmission in the CNS but additionally play an overlooked role in the periphery. GABAARs belong to the transmitter-gated ion channel superfamily, which includes 5-HT3, nicotinic and glycine receptors. They are composed of five transmembrane crossing subunits, arranged to form a central anion-conducting pore, or channel. The subunits are drawn from a repertoire of 19 gene products belonging to distinct families including: ?1-6; ?1-3; ?1-3, ?, ?, ?, ? and ?1-3. In the adult mammalian brain this diversity underpins the expression of 20-30 major GABAAR subtypes that are uniquely distributed and consequently influence particular behaviours. Not surprisingly, abnormal function of GABAA receptor-mediated inhibition has been implicated in the pathogenesis of many human neurological and psychiatric disorders that include epilepsy, insomnia, mood disorders and substance abuse. In this presentation, I will discuss our current understanding of the physiological, pathological and pharmacological significance of GABAA R diversity and the role of both environmental and genetic factors upon GABAAR physiology and pathology with a specific emphasis on the role of early-life experiences on GABAAR function and dysfunction.


Zur Webseite der Veranstaltung


Doktoratskolleg "MolTag"


Susanne Menschik-Zunzer
Department of Pharmacology and Toxicology
DK Molecular Drug Targets
01 5277 55320,