Donnerstag, 19. Dezember 2019, 16:00 - 17:00 iCal

MolTag Guest lecture by Elodie Laine, PhD

Functional protein sites deciphered by evolution and conformational dynamics

UZA 2, Seminar room 2D 404 (Block D, Level 4)
Althanstrasse 14, 1090 Vienna

Vortrag


The Doctoral Program ION CHANNELS AND TRANSPORTERS AS MOLECULAR DRUG TARGETS („MolTag“) is pleased to invite you to the following lecture

 

"Functional protein sites deciphered by evolution and conformational dynamics”

by Elodie LAINE, PhD, Laboratory of Computational and Quantitative Biology, Analytical Genomics team, Sorbonne Université, Paris, France

 

on: Thursday, December 19th, 2019, 04:00pm (16:00 Uhr)

at: UZA 2, Althanstr. 14, 1090 Vienna, Seminar Room 2D 404

 

ABSTRACT: Identifying functional protein sites and understanding which and how genetic variations alter them are central questions for bioengineering, medicine, and fundamental biology. Protein sequences, 3D shapes and motions have been exploited for decades to address these questions. The classical view is that the richer the description of proteins, the better, and hence protein structures should in principle be more informative than sequences. However, this view has been challenged by the recent access to massive amounts of sequence data, which have proven highly valuable. I will present several computational methods to identify interaction sites at protein surfaces and predict mutational outcomes. I will discuss the relative contributions of sequence- and structure-based information in addressing these problems.

 

RESEARCH PROFILE: Elodie Laine works as an associate professor in the Laboratory of Computational and Quantitative Biology (LCQB), at Sorbonne Université (Paris, France). She did her PhD and her post-doc in molecular modeling and structural dynamics, at Institut Pasteur and Ecole Normale Supérieure de Cachan, respectively. At LCQB, she started to develop methods for studying proteins at large scale and to include evolutionary aspects. [Google scholar profile: scholar.google.com/citations]

 

Contact: Doctoral Program MolTag, Dept. of Pharmacology and Toxicology; moltag.univie.ac.at, Office.moltag@univie.ac.at, phone: 01 4277 55320

 

Zur Webseite der Veranstaltung


Veranstalter

MolTag Doctoral Program


Kontakt

Susanne Menschik-Zunzer
Department of Pharmacology and Toxicology, UZA 2
DK Molecular Drug Targets
01 4277 55320
susanne.menschik-zunzer@univie.ac.at, office.moltag@univie.ac.at