Mittwoch, 10. April 2019, 16:15 - 17:00 iCal
Guest talk: Prof. Jimmy Wu, USA
Department of Chemistry, Dartmouth College, Hanover, USA
Total Synthesis and Biological Evaluation of Several
Nuphar Alkaloids and their Derivatives
Hörsaal 3 an der Fakultät für Chemie
Boltzmanngasse 1, 1090 Wien
Vortrag
The hydroxylated dimeric nuphar alkaloids are found in the common yellow water lily. In particular, 6-hydroxythiobinupharidine has been shown to induce apoptosis in human leukemia cell lines (U937) faster than any known small molecule. However, the only two studies concerning their biological mechanism of action are inconclusive. The first synthesis of any dimeric Nuphar alkaloids was reported in 2013, but was of an inac-tive compound. This lecture will describe our work in carrying out the first total syntheses of the biologically ac-tive hydroxylated dimeric nuphar alkaloids. We also report novel methods for preparing the quinolizidine core, as well as apoptosis data on several other compounds, including unnatural monomeric ana-logs previously unknown to nature.
Veranstalter
Fakultät für Chemie, Institut für Chemische Katalyse
Kontakt
Lena Yadlapalli
Dekanat der Fakultät für Chemie
+43-1-4277-52012
lena.yadlapalli@univie.ac.at
Erstellt am Donnerstag, 09. August 2018, 11:58
Letzte Änderung am Donnerstag, 03. Januar 2019, 12:44