Montag, 14. Mai 2018, 16:00 - 17:30 iCal

Fakultätskolloquium Chemie

Vorstellungsvorträge der HabilwerberInnen:

Dr. Stefanie Widder, CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienn: "Emergence of complex function in interacting biological communities”

Prof. Dr. Thomas L. Mindt, Ludwig Boltzmann Institute Applied Diagnostics: "Development of Radiolabelled Peptides and Proteins for Tumour Targeting"

Joseph Loschmidt Hörsaal der Fakultät für Chemie
Währinger Straße 42, 1090 Wien

Lecture


Dr. Stefanie Widder

CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna

“Emergence of complex function in interacting biological communities”

Reaction-diffusion systems like the Belousov-Zhabotinski reaction or Turing systems, are characterized by emergent spatial patterning and far-from equilibrium dynamics. Typically, the length scale of the macroscopic, ordered structures that allow the system to organize at a collective level, is independent of the underlying scale of microscopic interactions among components. Microbiota show similar properties. In detail, they constitute interacting communities, are subjected to matter and information flow and exhibit collective functional traits at the level of the ecosystem. In my talk I will show how the far-from equilibrium framework can be successfully applied to model these ‘microbial multi-particle systems’ with the objective to dissect emergent community func-tion. I will present examples from soil and lung communities and discuss the emergence of the keystone property that is essential for community robustness. I will take a stance on keystoneness as general property of structured, interacting communities and will show how we applied this attribute in big, biomedical data to predict drug targets for persons with chronic lung disease.

 

Prof. Dr. Thomas L. Mindt

Ludwig Boltzmann Institute Applied Diagnostics

“Development of Radiolabelled Peptides and Proteins for Tumour Targeting”

Application of metallic radionuclides in the development of tumour-targeting radiopharmaceuticals has the big advantage that it allows for exchanging the metal to obtain either diagnostic probes for imaging or agents for radioendotherapy (theranostic approach). The design and development of a radiometal-based tracer requires the optimization of each individual component of the conjugate (e.g., chelator, spacer, and vector) in order to fine-tune its chemical and biological properties. After a short introduction of the new Ludwig Boltzmann Insti-tute Applied Diagnostics, different research projects of Prof. Mindt’s laboratories will be presented to illustrate the importance of such efforts in the development of radiolabelled peptides and proteins for applications in nuclear oncology.


Veranstalter

Fakultät für Chemie


Kontakt

Lena Yadlapalli
Fakultät für Chemie der Universität Wien, Dekanat
+43-1-4277-52012
lena.yadlapalli@univie.ac.at