Montag, 09. April 2018, 16:00 - 17:30 iCal

Fakultätskolloquium Chemie: Prof. Manfred Jung, D

Universität Freiburg

"Chemical epigenetic - probing bookmarks in the book of life"

Hörsaal 2 der Fakultät für Chemie
Währinger Straße 42, 1090 Wien

Vortrag


Epigenetics is defined as inheritable changes in the phenotype of a cell or an organism that are regulated by mechanisms other than changes in the DNA sequence. Epigenetic mechanisms respond to external signals, e.g. chemicals, stress or nutrition, and affect transcriptional regulation. Epigenetics may preserve these effects even if the initial stimulus is not present any longer. It may be as stable as a genetic alteration but is still principally reversible. One of the major epigenetic mechanisms is the posttranslational modification of lysine residues in histone proteins which also occurs on other protein substrates. In this talk the principle mechanisms of epigenetics are introduced, selected epigenetic targets and available inhibitors are presented and studies from our own research on chemical tools to probe reversible histone acetylation and methylation are presented.


Veranstalter

Fakultät für Chemie


Kontakt

Lena Yadlapalli
Fakultät für Chemie der Universität Wien, Dekanat
+43-1-4277-52012
lena.yadlapalli@univie.ac.at