Montag, 21. November 2016, 17:00 - 18:00 iCal
Guest Lectury by Prof.Dr. David J. BEECH, U Leeds
"THE MAGIC AND POTENTIAL OF CALCIUM AND SODIUM ION SIGNALLING” by Prof.Dr. David J. BEECH
Leeds Institute of Cardiovascular and Metabolic Medicine
School of Medicine, University of Leeds
Pharmacy Building, Seminar room 2D 358 (Block D, Level 3); Dept. f. Pharmacology and Toxicology
Althanstraße 14, 1090 Vienna
Lecture
The Doctoral Program ION CHANNELS AND TRANSPORTERS AS MOLECULAR DRUG TARGETS („MolTag“) is pleased to invite you to the following lecture:
"THE MAGIC AND POTENTIAL OF CALCIUM AND SODIUM ION SIGNALLING” by Prof.Dr. David J. BEECH
Leeds Institute of Cardiovascular and Metabolic Medicine
School of Medicine, University of Leeds, UK; e-mail: d.j.beech@leeds.ac.uk
on: Monday, November 21st 2016, 05:00 pm (17:00 Uhr)
at: UZA II, Althanstraße 14, Seminar room 2D 358
My research addresses the calcium-permeable and sodium-permeable non-selective cationic channels of mammalian cells, the purposes these mechanisms serve and whether they can be exploited for therapeutic benefit. Specifically I am interested in the idea that certain types of channel are expressed in blood vessels in order to sense physical and chemical factors and couple them to remodelling of blood flow. I think the mechanisms are pivotal in major areas of mammalian biology and tractable as routes to new drugs for the treatment of certain types of cardiovascular disease and other non-communicable diseases which are prevalent in many societies globally. I am particularly focussed on Orai1, Piezo1 and TRPC1/4/5 channels. I have a research group of about 15 people working on the channels.
I originally read Pharmacology at the U Manchester UK before studying for a PhD in Prof Tom Bolton’s lab at George’s London. I then moved to the U Washington Seattle for postdoc research with Prof Bertil Hille before being awarded one of the first Wellcome Trust Postdoctoral Career Development Fellowships in 1990, initially in London and then Leeds where I became professor in 2000. I served as Senior Editor for the J of Physiology, was Head of the Dept of Biomedical Sciences for 3 years and, in 2007, founded and directed Leeds’ first constitutional structure for all cardiovascular research at Leeds (http://www.cardiovascular.leeds.ac.uk/ twitter.com/unileedscardio). I remain director of the cardiovascular centre and now also head the Division of Cardiovascular and Diabetes Research in the School of Medicine which contains about 80 staff members. I am a member of the British Heart Foundation (BHF) Chairs and Programme Grants Committee and direct the BHF 4-Year PhD Programme in Cardiovascular Disease and Diabetes. I have trained 41 postgraduate research students, published 135 peer-reviewed articles including in Nature and Nature-sister journals, delivered 62 invited lectures at conferences worldwide, was elected to Fellowship of the Academy of Medical Sciences in 2013 and became a Wellcome Trust Investigator in 2016.
Example publications: Akbulut, Y., Gaunt, H.J., Muraki, K., Ludlow, M.J., Amer, M.S., Bruns, A., Vasudev, N.S., Radtke, L., Willot, M., Hahn, S., Seitz, T., Ziegler, S., Christmann, M., *Beech, D.J., Waldmann, H. (2015). (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angewandte Chemie Int Ed. 54, 3787-3791. *Corresponding author.
Li, J., Hou, B., Tumova, S., Muraki, K., Bruns, A., Ludlow, M.J., Sedo, A., Hyman, A.J., McKeown, L., Young, R.S., Yuldasheva, N.Y., Majeed, Y., Wilson, L.A., Rode, B., Bailey, M.A., Kim, H.R., Fu, Z., Carter, D.A.L., Bilton, J., Imrie, H., Ajuh, P., Dear, T.N., Cubbon, R.M., Kearney, M.T., Prasad, K.R., Evans, P.C., Ainscough, J.F.X., Beech, D.J. (2014). Piezo1 integration of vascular architecture with physiological force. Nature 515, 279-282.
Contact: Doctoral Program MolTag, Dept. of Pharmacology and Toxicology; moltag.univie.ac.at, Office.moltag@univie.ac.at
Veranstalter
Kontakt
Susanne Menschik-Zunzer
Department of Pharmacology and Toxicology
DK Molecular Drug Targets
01 5277 55320
susanne.menschik-zunzer@univie.ac.at, office.moltag@univie.ac.at
Erstellt am Dienstag, 18. Oktober 2016, 12:31
Letzte Änderung am Mittwoch, 19. Oktober 2016, 08:44