Donnerstag, 08. März 2018, 15:00 - 16:30 iCal

Guest talk: Ass. Prof. Norbert Lange, Switzerland

School of Pharmaceutical Sciences, University of Geneva

"From Flowers, Kings, Vampires, Sepia, Bugs, and Cancer"

Kleiner Hörsaal 4
Währinger Straße 42, 1090 Wien

Lecture

The preferential induction of fluorescent and phototoxic protoporphyrin IX (PPIX) following the exogenous ad-ministration of 5-aminolevulinic acid (5-ALA) is one of the most selective phenomenon in oncology. However, 5-ALA’s use in clinical practice is hampered by the hydrophilic character. The introduction of lipophilic derivatives of the naturally occurring heme precursor of 5-ALA into photomedicine, has led to a true revival of this research area. 5-ALA-mediated photodynamic therapy (PDT) and fluorescence photodetection (FD) of neoplastic disease is probably one of the most selective cancer treatments currently known in oncology. Until today, this method has been assessed experimentally for the treatment of various medical indications. However, the limited local bioavailability of 5-ALA has widely hampered its access to daily clinical practice until today. Although researches became aware of this drawback already early in the development of 5-ALA-mediated PDT, only recently, well established concepts in pharmaceutical science were adapted to this methodology. Currently, two derivatives of 5-ALA, methylaminolevulinate (MAL) and hexylaminolevulinate (HAL) gained marketing authorization from the regulatory offices in Europe and Australia. MAL is marketed under the trade name Metvix® for the treatment of actinic keratosis (AK) and difficult-to-treat basal cell carcinoma (BCC), HAL has recently been launched under the trade name Hexvix® for the improved diagnosis of superficial bladder cancer in Europe. Now, we have de-veloped nano-micelle forming 5-ALA derivatives, appropriate for systemic administration, aiming at enlarging their field of administration.

Veranstalter

Fakultät für Chemie, Institut für Anorganische Chemie

Kontakt

Lena Yadlapalli
Fakultät für Chemie der Universität Wien, Dekanat
+43-1-4277-52012
lena.yadlapalli@univie.ac.at

Erstellt am Freitag, 09. Februar 2018, 14:42
Letzte Änderung am Montag, 12. Februar 2018, 08:40

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