Mittwoch, 21. Juni 2017, 11:00 - 13:00 iCal
Fakultät Chemie und Chemische Biologie (CCB), Technische Universität Dortmund, Deutschland
"PdII and PtII Coordination Chemistry with Nucleobases: Analogies, Differences, and Combinations of the two Metal Ions"
Kleiner Hörsaal 4 der Fakultät für Chemie
Währinger Straße 42, 1090 Wien
PdII and PtII Coordination Chemistry with Nucleobases: Analogies, Differences, and Combinations of the two Metal Ions
Contrary to earlier expectations that PdII might produce antitumor active coordination complexes similar to those of PtII, and despite some 850 PdII
compounds tested thus far, there is today no single Pd containing drug in clinical use. Moreover, presently no hard evidence exists that Pd analogues of active Pt drugs interact with DNA in a way the latter do. The question may be raised as to why this is the case.
The lecture will start out with a short tutorial regarding similarities and differences in the coordination chemistry of PdII and PtII and will focus then on their interactions with nucleobases. Differential affinities for nucleobase donor atoms based on differences in kinetics will be discussed. Given the wide-spread use of PdII and specifically of (en)PdII in Supramolecular Chemistry, examples will also be presented in which discrete Pt-nucleobase entities are extended into larger constructs by means of PdII moieties. Although unlikely to be of any biological relevance, they reflect the large potential nucleobases have as supramolecular building blocks.
Fakultät für Chemie der Universität Wien
Erstellt am Mittwoch, 14. Juni 2017, 11:33
Letzte Änderung am Mittwoch, 14. Juni 2017, 17:19